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Embryology Study Offers Clues To Birth Defects
Gregg Duester, Ph.D., professor of developmental biology at Burnham Institute for Medical Research (Burnham), along with Xianling Zhao, Ph.D., and colleagues, have clarified the role that retinoic acid plays in limb development. The study showed that retinoic acid controls the development (or budding) of forelimbs, but not hindlimbs, and that retinoic acid is not responsible for patterning (or differentiation of the parts) of limbs. This research corrects longstanding misconceptions about limb development and provides new insights into congenital limb defects. The study was published online in the journal Current Biology on May 21.

What Are Gallstones? What Causes Gallstones?
Gallstones are lumps or stones that develop in the gallbladder or bile duct. Some of the chemicals which exist in the gallbladder, such as cholesterol, calcium bilirubinate, and calcium carbonate, harden into either one large stone or many small ones. According to Medilexicon"s medical dictionary, a gallstone is "A concretion in the gallbladder or a bile duct, composed chiefly of a mixture of cholesterol, calcium bilirubinate, and calcium carbonate, occasionally as a pure stone composed of just one of these substances". An article describes a gallbladder in the bile duct similar to trying to squeeze a golf ball through a straw.
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Spectranetics Receives CE Mark Approval For ThromCat(R)XT
Spectranetics Corporation (Nasdaq:SPNC) reported that it has received the CE mark approval for its next-generation ThromCat® XT Thrombus Removal System, a single-use, disposable device indicated for mechanical removal of thrombus from native coronary arteries and infra-inguinal arteries. The launch of the product will commence immediately within the European Union. The approval triggers a milestone payment of $1.5 million pursuant to the Company"s Amended Development and Regulatory Services agreement with Kensey Nash Corporation (Nasdaq:KNSY).
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Continued International Investment, Decreased Discrimination Key To Fight Against HIV/AIDS, Says U.N. Secretary-General

U.N. Secretary-General Ban Ki-Moon during a General Assembly meeting Tuesday urged governments not to cut aid for the international fight against HIV/AIDS, the AP/Washington Post reports. Even as Ban "called for "bold action" not only to increase funding but also to break down social barriers to achieve the goal set by world leaders in 2006 of universal access to comprehensive HIV prevention services, treatment, care and support by 2010," he and other speakers at the meeting "reviewing progress and challenges in the battle against AIDS indicated that it will be exceedingly difficult - if not impossible - to reach the goal" (Lederer, AP/Washington Post, 6/16). During the meeting, Ban presented a report (pdf) on the progress of HIV/AIDS commitments, that showed "achieving national universal access targets by 2010 will require an estimated annual outlay of $25 billion within two years," Xinhua reports. "Now is not the time to falter," Ban said. "The economic crisis should not be an excuse to abandon commitments - it should be an impetus to make the right investments that will yield benefits for generations to come" (Xinhua, 6/16). Ban highlighted positive indicators from his report, including the results of a survey of 14 African countries that showed a drop in the percentage of pregnant women who are HIV-positive (AP/Washington Post, 6/16); an increase in funding for HIV/AIDS programs in middle- and low-income countries, from $11.3 billion in 2007 to $13.7 billion in 2008 (UNAIDS release, 6/16); and that "the provision of antiretroviral drugs increased, contributing to the first decline in the number of annual AIDS deaths since the epidemic was first recognized nearly 30 years ago," according to the AP/Washington Post. "Yet, there are still nearly five new infections for every two people put on treatment," Ban said. The AP/Washington Post writes, "General Assembly President Miguel d"Escoto Brockmann cited other shortcomings: 29 million people who need HIV treatment still lack medication, roughly two out of three HIV-positive pregnant women don"t receive services to prevent mother-to-child transmission, and an estimated 370,000 children under the age of 15 became infected with HIV in 2007 and are less likely than adults to receive treatment." "Even as we see signs of cutbacks in AIDS funding in many countries, we must remind governments and the international community that the world has the res to mount the kind of AIDS response to which we have committed. If we allow cuts now, we will face increased costs and great human suffering in the future," d"Escoto said (Lederer, AP/Washington Post, 6/16). "The Secretary-General"s report also highlights that despite the many commitments made by member states to protect the rights of people living with HIV and people vulnerable to HIV infection, many countries have laws and policies that are inconsistent with the commitments and result in reduced access to essential HIV services and commodities," according to UNAIDS (UNAIDS release, 6/16). This information was reprinted from globalhealth.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Global Health Policy Report, search the archives and sign up for email delivery at globalhealth.kff.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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