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Researchers Plan To Target Immune Cells Responsible For Eluding Antiretroviral Treatment
Certain human immune cells known as macrophages are composed of hybrid HIV strains that elude treatment and antiretroviral drugs, according to a new study by researchers from the University of Florida and other institutions, the Gainesville Sun reports. For the study, researchers examined tissue from HIV-positive people and discovered that as much as half of the macrophages present were hybrids, made from genetic material from several HIV viruses that when combined formed new HIV strains. Marco Salemi -- assistant professor of pathology, immunology and laboratory medicine at the University of Florida"s College of Medicine -- said that macrophages likely make HIV more aggressive over time, adding, "If we want to eradicate HIV, we need to find a way to actually target the virus specifically infecting the macrophages." According to the Sun, current research and treatment target T-cells, and although antiretrovirals are effective at blocking infection from new cells and lowering viral loads, they are unable to reduce the viral level in an HIV-positive person to zero. The Sun notes that macrophages can be targeted by HIV multiple times, and once they are infected, they can live for months, unlike T-cells. The team of researchers, led by Michael McGrath of the University of California - San Francisco, is developing macrophage-targeting drugs through a grant from the National Institute of Mental Health, the Sun reports (Chun, Gainesville Sun, 5/28).
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China Quarantines New Orleans Mayor And Wife Over Swine Flu
Although they have no symptoms themselves, the mayor of New Orleans, Louisiana, USA, Ray Nagin, his wife and a member of his security staff
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Role For Innate, Not Adaptive, Immunity Revealed By Autoinflammatory Disease Model
Researchers at the University of California, San Diego School of Medicine have developed the first mouse model for auto-inflammatory diseases, disorders that involve the over-activation of the body"s innate, primitive immune system. Their study, published early on-line in Cell Immunity on June 4, suggests that the innate - not adaptive - immune system drives auto-inflammatory diseases. The findings could open new therapeutic directions for research into disorders such as gout or inflammatory bowel disease.
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Elsevier's PharmaPendium Introduces The FDA Classic Collection

PharmaPendium, Elsevier"s online re for authoritative preclinical, clinical and post-marketing drug information, has significantly expanded its coverage of US Food and Drug Administration (FDA) approval documents with the launch of the FDA Classic Collection. This collection contains all available historical FDA approval documents up to and including those issued in 1991 - all indexed and made searchable for the first time in history. With the addition of the FDA Classic Collection, PharmaPendium has become the only integrated, searchable of all FDA drug approval documents. The combination of PharmaPendium"s current FDA database and the FDA Classic Collection creates an entire searchable library of documents written by the FDA on the approval of drugs and their pharmacokinetics, efficacy and safety. The FDA Classic Collection may be searched simultaneously with the current file (1992-present) or as a discrete database. "For success within the pharmaceutical industry it"s critical to gain and maintain a strong competitive advantage and avoid lost opportunities, lost sales, wasted trials and regulatory recycling. The addition of the FDA Classic Collection to PharmaPendium gives pharmaceutical companies the advantage of being able to gain a unique perspective into the past, enabling them to benefit from information that has not been available for close to 50 years. Users will be able to apply modern analyses tools to these data for the first time, generating new insights. They will no longer encounter information dead ends because every citation to a previous FDA document is now traceable, searchable and viewable," commented Philip MacLaughlin, Senior Product Manager at Elsevier. Most of the documents in PharmaPendium"s FDA Classic Collection were previously available only through direct requests to the FDA/Center for Drug Evaluation and Research Freedom of Information Office and had to be pulled from microfiche. "Now users can locate and search these historic documents in just seconds to uncover regulatory precedents, learn from historic mistakes and successes and apply these lessons to current projects in the drug pipeline," continued MacLaughlin. The FDA Classic Collection may be added to new or existing PharmaPendium licenses for an additional fee. PharmaPendium is a trademark of Elsevier Inc. Tom Reller Elsevier


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