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Bacteria Are First Sensed By Cells Lining Blood Vessels, Not Immune Cells
Paul Kubes and colleagues, at the University of Calgary, Canada, have provided evidence in mice to refute the paradigm that the initial phase of the immune response to infection with Gram-negative bacteria (the recruitment of immune cells known as neutrophils to the site of infection) is triggered following immune sentinel-cell recognition of the bacterial molecule LPS via the protein TLR4. Rather, the researchers found that LPS recognition by TLR4 on the cells that line blood vessels (endothelial cells) is the crucial event that initiates neutrophil recruitment and bacterial clearance in mice.

Climate Change, Hunger, Economy G8 Summit Top Priorities; France's First Lady Calls On G8 To Expand On Global Health 'Achievements'
President Barack Obama joined world leaders in Italy on Wednesday for "three days of intense talks on threats to global security and stability" at a G8 summit "where climate change, the continuing global economy crisis and world hunger got top billing," AP/Google.com reports (Babington, 7/8).
News of the day
Promising Antimicrobial Attacks Virus, Stimulates Immune System
A promising antimicrobial agent already known to kill bacteria can also kill viruses and stimulate the innate immune system, according to researchers at National Jewish Health. In a paper appearing online June 4 in the Journal of Investigative Dermatology, Michael Howell, PhD, Assistant Professor of Pediatrics, and his colleagues demonstrated that the synthetic compound CSA-13 can kill vaccinia virus in cell cultures and in mice. Additionally, they showed that CSA-13 stimulates cells to produce their own antimicrobial proteins.
Sexual Health

Funding For Medical Equipment

Health boards across Scotland will share ÷£30 million in funding for new medical equipment this year. The money will allow them to purchase equipment ranging from blood pressure monitors to ultrasound equipment, mobile X-ray machines, endoscopes and MRI scanners. Public Health Minister Shona Robison said the funding meant patients across Scotland would continue to benefit from state-of-the-art healthcare. Ms Robison today visited the New Victoria Hospital in Glasgow to see a new ÷£1.1 million MRI scanner bought with last year"s medical equipment funding being installed. She said: "This funding for medical equipment will ensure that patients across Scotland continue to benefit from state-of-the-art facilities. "Up-to-the-minute technology is crucial for effective diagnosis and treatment and this funding will allow NHS boards right across the country to purchase equipment ranging from specialised care beds to expensive scanners. And it means our NHS staff working on the frontline will have the equipment they need to carry out their jobs most effectively." The investment forms part of this year"s record investment in NHS Scotland of ÷£11.09 billion, but is additional to the ÷£8.64 billion of this which has gone to NHS boards in revenue and capital funding for 2009-10. Referring to the newly-installed MRI scanner at the New Victoria Hospital, Andrew Robertson, Chairman of NHS Greater Glasgow and Clyde, said: "This is the first time that south east Glasgow patients have been able to directly access a MRI scan, and the first time also they have had local access to renal dialysis and chemotherapy. "The superlative facilities, staff and equipment of the New Victoria show the reality of what can be achieved by using national funding to transform local services." Nexxus, Scotland


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