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Oncothyreon Announces Presentation Of Long-term Stimuvax Data At World Conference On Lung Cancer
Oncothyreon Inc. (Nasdaq: ONTY) (TSX:ONY) (the "Company") announced that clinical data relating to long-term treatment with Stimuvax were presented at the International Association for the Study of Lung Cancer"s 13th World Conference on Lung Cancer in San Francisco on August 1, 2009. The presentation by Dr. Glenwood Goss from the Ottawa Hospital Cancer Centre, Ottawa, Ontario, involved 16 patients who received treatment with Stimuvax for between 2 and 8.2 years as part of the Phase 2b trial in patients with stage IIIb/IV non-small cell lung cancer (NSCLC).

Ventana's Promising New Anti-Obesity Patent
Ventana Biotech Inc ("Ventana")(PINK SHEETS:VNTA), a biotechnology company that is developing a appetite-suppressing chewing gum, released detailed information about its innovative Anti-Obesity Chewing Gum.
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Diabetes Specialists Call For Drug Regulators To Step In To Clarify Lantus Concerns, UK
BRITAIN"S top diabetes specialists added their weight to calls for European drug regulatory bodies to launch an urgent investigation into the popular insulin treatment glargine (Lantus). The move by the Association of British Clinical Diabetologists (ABCD) follows this week"s publication of four studies, which raise possible concern about an increased risk of the development of cancer in people who use this long-acting insulin therapy.
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Microproteinuria: Indicator To Monitor CNI-Related Nephrotoxicity In Liver Transplant Recipients?

Deterioration of renal function with CNI therapy has been widely reported in liver transplant recipients. Microproteinuria has been used to monitor the early changes of nephropathy in renal disease or cardiovascular events. However, whether microproteinuria could be used as an early and sensitive indicator to monitor CNI-related nephrotoxicity in liver transplant recipients has not been unequivocally addressed. A research article published in the World Journal of Gastroenterology addresses this question. The research team led by Professor Yan from West China Hospital of Sichuan University studied the use of microproteinuria in early diagnosis of CNI-related nephrotoxicity after liver transplantation. Measurements of microproteinuria including 1-microglobulin (1m), 2-microglobulin (2m), immunoglobulin, microalbumin and transferrin were performed with a Dade Behring array nephelometry system. Follow-up data of this study demonstrated that there was a downward trend in renal function over time, with the persistence of microproteinuria. The urinary concentration of 2m and 1m significantly increased with the subtle changes in renal function in the study groups, but the levels of SCr and BUN significantly increased only when renal function was severely damaged by CNI nephrotoxicity. The subsequent reductions in GFR were closely correlated with the increases in ΁1m and 2m. Fewer patients were found to have 2m in the urine than 1m in this study as 2m is unstable in fresh urine. This problem can partly be overcome by maintaining the urine pH value (by adding basic buffer to the urine) to prevent the degradation of 2m. This study suggested that urinary 2m and ΁1m are sensitive urinary markers for detecting CNI-related nephrotoxicity in liver transplant recipients. The results are interesting and may represent a screening method to prevent the progression of CNI-related subclinical renal dysfunction after liver transplantation. Reference: Li J, Liu B, Yan LN, Wang LL, Lau WY, Li B, Wang WT, Xu Q, Yang JY, Li FG. Microproteinuria for detecting calcineurin nhibitor-related nephrotoxicity after liver transplantation. World J Gastroenterol 2009; 15(23): 2913-2917 http://www.wjgnet.com/1007-9327/15/2913.asp Correspondence to: Lu-Nan Yan, Division of Liver ransplantation, West China Hospital, Sichuan University, hengdu 610041, China. Lin Tian World Journal of Gastroenterology


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