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Arete Therapeutics Presents Positive Clinical And Preclinical Data For AR9281
Arete Therapeutics Inc. announced the presentation of three posters that validate the mechanistic activity and therapeutic potential of the company"s lead drug candidate, AR9281, an orally-administered soluble epoxide hydrolase (sEH) inhibitor that is in a Phase II clinical program for the treatment of type 2 diabetes. sEH is an enzyme involved in the metabolism of arachidonic acid, a key signaling molecule implicated in diabetes, hypertension and inflammatory disorders.

Preventable Maternal Deaths Should Be Recognized As Women's Rights Violations, Opinion Piece Says
"Human rights organizations around the world are starting to demand that governments recognize preventable maternal death as a violation of women"s rights," Mary Robinson and Alicia Yamin, both advisory council members of the International Initiative on Maternal Mortality and Human Rights, write in a Boston Globe opinion piece. They add that with the "United Nations Human Rights Council"s June session just around the corner, governments have a chance to prove that they value women"s lives by taking concrete action on this issue." According to Robinson and Yamin, "[m]ore than one woman dies every minute from preventable causes in childbirth, and for every woman who dies as many as 30 others are left with lifelong, debilitating complications."They continue, "Moreover, when mothers die, children are at greater risk of dropping out of school, becoming malnourished and simply not surviving," adding, "Not only is maternal mortality and morbidity a global health emergency, but it triggers and aggravates cycles of poverty that cause generations of suffering and despair." The authors write, "Asserting that these preventable deaths are an issue of human rights does not mean that poor governments are going to be blamed for not doing what they cannot do." Instead, "understanding the profound injustice of disparities in maternal deaths makes it all the more urgent that donor states honor their funding commitments and that effective monitoring and accountability mechanisms are put in place to ensure that aid is going to the interventions that evidence has shown will save women"s lives," they add.According to Robinson and Yamin, Secretary of State Hillary Rodham Clinton 14 years ago at the Fourth World Conference on Women, then U.S. first lady, "declared that "women"s rights are human rights."" They add that Clinton recently has "passionately and eloquently affirmed [the Obama] administration"s commitment to women"s reproductive health needs around the world, and the Obama administration has called for increased funding for global health." They conclude, "As a new member of the Human Rights Council, the United States has the chance to lead the way in promoting a woman"s right to go through pregnancy and childbirth in safety and, just as important, to back up that assertion with adequate funding commitments" (Robinson/Yamin, Boston Globe, 6/4).
News of the day
Rib-X Pharmaceuticals Reports Positive Phase 2 Study Results For Radezolid In Community-Acquired Pneumonia
Rib-X Pharmaceuticals, Inc. ("Rib-X" or the "Company"), a development-stage company focused on the discovery, development and commercialization of novel antibiotics for the treatment of antibiotic-resistant infections, today announced positive results from a Phase 2 clinical trial of radezolid in the treatment of community-acquired pneumonia (CAP).
Endocrinology

NHS Celebrates Success And Progress In A&E, England

New figures published show A&E departments in England have met the operational standard for 98% of patients to be treated within four hours of arrival at A&E over the last year. Although the number of patients attending A&E continued to increase last year with 19.6 million visits recorded across England, NHS staff have continued to deliver the same excellent standards of care with almost all of these seen, diagnosed and treated within four hours of arriving at A&E departments. "This is a tremendous achievement by NHS staff who continue to deliver fast, safe, high quality care to a growing number of A&E patients, especially given that thiHealth Minister Ben Bradshaw said: Winter was the most challenging for years. "Patients tell us the time spent in A&E matters to them, which is why A&E waiting times continue to be a priority. Nurses have told me how ambulance staff used to queue out of the door with patients on trolleys before the four-hour standard was introduced. "Thanks to the hard work of NHS staff the waiting experience for millions of patients in A&E has dramatically improved - especially when we consider that, before the target was introduced, almost a quarter of patients spent more than four hours in A&E." Whilst dealing with seasonal flu and the worst weather conditions in recent years, the NHS has still achieved it"s best recorded performance in winter, with 97.7% of patients treated within four hours of arrival at A&E from January to March. Although this is just short of the operational standard it shows that winter preparations across the NHS are bringing real improvements to patients" experiences. This achievement is the result of sustained investment and innovation within A&E departments. There are now over 1,800 extra staff working in emergency care across England including an additional 749 consultants. At the same time, the NHS has more than doubled the amount of money spent on A&E services from ÷£750m in 1997/98 to ÷£1,732m in 2007/08. This increase in investment has been supported by the introduction of new ways for patients to access emergency care such as Urgent Care Centres, Walk-in Centres and Minor Injuries Clinics, bringing the right treatment closer to the patient. Notes 1. The A&E performance data is available on-line. 2. The target that no patient would spend more than four hours in accident and emergency departments from arrival to admission, transfer or discharge, was set in the NHS Plan in 2000. 3. In 2003, a 98 per cent minimum operating standard was set to allow for the minority of patients that clinically require more than four hours in A&E. NHS


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